abstract：BACKGROUND:Experimental tools for studying the complex steroidogenic interactions that occur between placenta and fetus during human pregnancy are extremely limited. OBJECTIVES:We aimed to develop a co-culture model to study steroidogenesis by the human fetoplacental unit and its disruption by exposure to environmenta...

journal_title：Environmental health perspectives

authors： Hudon Thibeault AA,Deroy K,Vaillancourt C,Sanderson JT

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Genetics may partially explain observed heterogeneity in associations between traffic-related air pollution and incident asthma. OBJECTIVE:Our aim was to investigate the impact of gene variants associated with oxidative stress and inflammation on associations between air pollution and incident childhood ast...

journal_title：Environmental health perspectives

authors： MacIntyre EA,Brauer M,Melén E,Bauer CP,Bauer M,Berdel D,Bergström A,Brunekreef B,Chan-Yeung M,Klümper C,Fuertes E,Gehring U,Gref A,Heinrich J,Herbarth O,Kerkhof M,Koppelman GH,Kozyrskyj AL,Pershagen G,Postma DS,Th

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Understanding the potential links between extreme weather events and human health in India is important in the context of vulnerability and adaptation to climate change. Research exploring such linkages in India is sparse. OBJECTIVES:We evaluated the association between extreme precipitation and gastrointes...

journal_title：Environmental health perspectives

authors： Bush KF,O'Neill MS,Li S,Mukherjee B,Hu H,Ghosh S,Balakrishnan K

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Concern persists over endocrine-disrupting effects of persistent organic pollutants (POPs) on human growth and sexual maturation. Potential effects of toxicant exposures on testosterone levels during puberty are not well characterized. OBJECTIVES:In this study we evaluated the relationship between toxicants...

journal_title：Environmental health perspectives

authors： Schell LM,Gallo MV,Deane GD,Nelder KR,DeCaprio AP,Jacobs A,Akwesasne Task Force on the Environment.

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Diethylstilbestrol (DES) is a synthetic estrogen associated with adverse effects on reproductive organs. DES-induced toxicity of the mouse seminal vesicle (SV) is mediated by estrogen receptor α (ERα), which alters expression of seminal vesicle secretory protein IV (Svs4) and lactoferrin (Ltf) genes. OBJECT...

journal_title：Environmental health perspectives

authors： Li Y,Hamilton KJ,Lai AY,Burns KA,Li L,Wade PA,Korach KS

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Globally, 2.8 billion people rely on household solid fuels. Reducing the resulting adverse health, environmental, and development consequences will involve transitioning through a mix of clean fuels and improved solid fuel stoves (IS) of demonstrable effectiveness. To date, achieving uptake of IS has present...

journal_title：Environmental health perspectives

authors： Rehfuess EA,Puzzolo E,Stanistreet D,Pope D,Bruce NG

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Tens of millions of Americans suffer from a range of adverse health outcomes due to noise exposure, including heart disease and hearing loss. Reducing environmental noise pollution is achievable and consistent with national prevention goals, yet there is no national plan to reduce environmental noise polluti...

journal_title：Environmental health perspectives

authors： Hammer MS,Swinburn TK,Neitzel RL

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Anogenital distance (AGD) in animals is a sensitive biomarker of fetal endocrine disruption and the associated testicular dysgenesis syndrome (TDS). However, AGD in human infants with cryptorchidism and hypospadias, which are potential manifestations of TDS during childhood, is not clearly described. OBJECT...

journal_title：Environmental health perspectives

authors： Thankamony A,Lek N,Carroll D,Williams M,Dunger DB,Acerini CL,Ong KK,Hughes IA

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Climate influences dengue ecology by affecting vector dynamics, agent development, and mosquito/human interactions. Although these relationships are known, the impact climate change will have on transmission is unclear. Climate-driven statistical and process-based models are being used to refine our knowledg...

journal_title：Environmental health perspectives

authors： Morin CW,Comrie AC,Ernst K

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Previous research suggests perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) may be associated with adverse pregnancy outcomes. OBJECTIVE:We conducted a population-based study of PFOA and PFOS and birth outcomes from 2005 through 2010 in a Mid-Ohio Valley community exposed to high levels of...

journal_title：Environmental health perspectives

authors： Darrow LA,Stein CR,Steenland K

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Associations between airborne particles and health outcomes have been documented worldwide; however, there is limited information regarding health effects associated with different particle sizes. OBJECTIVES:We explored the association between size-fractionated particle number concentrations (PNCs) and dail...

journal_title：Environmental health perspectives

authors： Meng X,Ma Y,Chen R,Zhou Z,Chen B,Kan H

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Environmental exposures to phthalates, particularly high-molecular-weight (HMW) phthalates, are suspected to contribute to allergy. OBJECTIVE:We assessed whether phthalate metabolites are associated with allergic symptoms and sensitization in a large nationally representative sample. METHODS:We used data o...

journal_title：Environmental health perspectives

authors： Hoppin JA,Jaramillo R,London SJ,Bertelsen RJ,Salo PM,Sandler DP,Zeldin DC

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Studies estimating health effects of long-term air pollution exposure often use a two-stage approach: building exposure models to assign individual-level exposures, which are then used in regression analyses. This requires accurate exposure modeling and careful treatment of exposure measurement error. OBJEC...

journal_title：Environmental health perspectives

authors： Bergen S,Sheppard L,Sampson PD,Kim SY,Richards M,Vedal S,Kaufman JD,Szpiro AA

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Inorganic arsenic (iAs) causes cancer and possibly other adverse health outcomes. Arsenic-based drugs are permitted in poultry production; however, the contribution of chicken consumption to iAs intake is unknown. OBJECTIVES:We sought to characterize the arsenic species profile in chicken meat and estimate ...

journal_title：Environmental health perspectives

authors： Nachman KE,Baron PA,Raber G,Francesconi KA,Navas-Acien A,Love DC

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Childhood lead exposure has been associated with growth delay. However, the association between blood lead levels (BLLs) and insulin-like growth factor 1 (IGF-1) has not been characterized in a large cohort with low-level lead exposure. METHODS:We recruited 394 boys 8-9 years of age from an industrial Russi...

journal_title：Environmental health perspectives

authors： Fleisch AF,Burns JS,Williams PL,Lee MM,Sergeyev O,Korrick SA,Hauser R

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:World Trade Center (WTC) rescue and recovery workers were exposed to a complex mix of pollutants and carcinogens. OBJECTIVE:The purpose of this investigation was to evaluate cancer incidence in responders during the first 7 years after 11 September 2001. METHODS:Cancers among 20,984 consented participants ...

journal_title：Environmental health perspectives

authors： Solan S,Wallenstein S,Shapiro M,Teitelbaum SL,Stevenson L,Kochman A,Kaplan J,Dellenbaugh C,Kahn A,Biro FN,Crane M,Crowley L,Gabrilove J,Gonsalves L,Harrison D,Herbert R,Luft B,Markowitz SB,Moline J,Niu X,Sacks H,

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:In the United States, most of the treated sewage sludge (biosolids) is applied to farmland as a soil amendment. Critics suggest that rules regulating sewage sludge treatment and land application may be insufficient to protect public health and the environment. Neighbors of land application sites report illne...

journal_title：Environmental health perspectives

authors： Lowman A,McDonald MA,Wing S,Muhammad N

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:According to a wide variety of analyses and projections, the potential effects of global climate change on human health are large and diverse. The U.S. National Institutes of Health (NIH), through its basic, clinical, and population research portfolio of grants, has been increasing efforts to understand how ...

journal_title：Environmental health perspectives

authors： Jessup CM,Balbus JM,Christian C,Haque E,Howe SE,Newton SA,Reid BC,Roberts L,Wilhelm E,Rosenthal JP

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Cadmium (Cd) is a human toxicant and carcinogen. Genetic variation might affect long-term accumulation. Cd is absorbed via iron transporters. OBJECTIVES:We evaluated the impact of iron homeostasis genes [divalent metal transporter 1 (SLC11A2), transferrin (TF), transferrin receptors (TFR2 and TFRC), and fer...

journal_title：Environmental health perspectives

authors： Rentschler G,Kippler M,Axmon A,Raqib R,Ekström EC,Skerfving S,Vahter M,Broberg K

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Prenatal and early-life periods may be critical windows for harmful effects of air pollution on infant health. OBJECTIVES:We studied the association of air pollution exposure during pregnancy and the first year of life with respiratory illnesses, ear infections, and eczema during the first 12-18 months of a...

journal_title：Environmental health perspectives

authors： Aguilera I,Pedersen M,Garcia-Esteban R,Ballester F,Basterrechea M,Esplugues A,Fernández-Somoano A,Lertxundi A,Tardón A,Sunyer J

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:The toxicity of many xenobiotic compounds is believed to involve oxidative injury to cells. Direct assessment of mechanistic events involved in xenobiotic-induced oxidative stress is not easily achievable. Development of genetically encoded probes designed for monitoring intracellular redox changes represent...

journal_title：Environmental health perspectives

authors： Gibbs-Flournoy EA,Simmons SO,Bromberg PA,Dick TP,Samet JM

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Exposure to arsenic via drinking water is a global environmental health problem. In utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in early adulthood. OBJECTIVES:We aimed to investigate how arsenic exposu...

journal_title：Environmental health perspectives

authors： Ramsey KA,Bosco A,McKenna KL,Carter KW,Elliot JG,Berry LJ,Sly PD,Larcombe AN,Zosky GR

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Bisphenol A (BPA) is widely used in the manufacture of polycarbonate plastic bottles, food and beverage can linings, thermal receipts, and dental sealants. Animal and human studies suggest that BPA may disrupt thyroid function. Although thyroid hormones play a determinant role in human growth and brain devel...

journal_title：Environmental health perspectives

authors： Chevrier J,Gunier RB,Bradman A,Holland NT,Calafat AM,Eskenazi B,Harley KG

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Air pollution exposure during pregnancy might affect placental growth and function, perhaps leading to pregnancy complications. OBJECTIVE:We prospectively evaluated the associations of maternal air pollution exposure with markers of placental growth and function among 7,801 pregnant women in the Netherlands...

journal_title：Environmental health perspectives

authors： van den Hooven EH,Pierik FH,de Kluizenaar Y,Hofman A,van Ratingen SW,Zandveld PY,Russcher H,Lindemans J,Miedema HM,Steegers EA,Jaddoe VW

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Recent findings suggest that maternal smoking during pregnancy may play a role in the development of metabolic alterations in offspring during childhood. However, whether such exposure increases the risk of developing similar metabolic alterations during adulthood is uncertain. OBJECTIVE:We evaluated the as...

journal_title：Environmental health perspectives

authors： Cupul-Uicab LA,Skjaerven R,Haug K,Travlos GS,Wilson RE,Eggesbø M,Hoppin JA,Whitworth KW,Longnecker MP

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Many pesticides in current use have recently been revealed as in vitro androgen receptor (AR) antagonists, but information about their combined effects is lacking. OBJECTIVE:We investigated the combined effects and the competitive AR antagonism of pesticide mixtures. METHODS:We used the MDA-kb2 assay to te...

journal_title：Environmental health perspectives

authors： Orton F,Rosivatz E,Scholze M,Kortenkamp A

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:The emerging consensus that exposure to near-roadway traffic-related pollution causes asthma has implications for compact urban development policies designed to reduce driving and greenhouse gases. OBJECTIVES:We estimated the current burden of childhood asthma-related disease attributable to near-roadway an...

journal_title：Environmental health perspectives

authors： Perez L,Lurmann F,Wilson J,Pastor M,Brandt SJ,Künzli N,McConnell R

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:In animals, some phthalates impair male reproductive development and function. Epidemiological studies have reported inconsistent evidence of associations between phthalates and markers of human testicular function. OBJECTIVES:We aimed to provide estimates of the effects of phthalate exposure on reproductiv...

journal_title：Environmental health perspectives

authors： Joensen UN,Frederiksen H,Blomberg Jensen M,Lauritsen MP,Olesen IA,Lassen TH,Andersson AM,Jørgensen N

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Cadmium is a commonly occurring toxic food contaminant, but health consequences of early-life exposure are poorly understood. OBJECTIVES:We evaluated the associations between cadmium exposure and neurobehavioral development in preschool children. METHODS:In our population-based mother-child cohort study in...

journal_title：Environmental health perspectives

authors： Kippler M,Tofail F,Hamadani JD,Gardner RM,Grantham-McGregor SM,Bottai M,Vahter M

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:During May-June 2010, a childhood lead poisoning outbreak related to gold ore processing was confirmed in two villages in Zamfara State, Nigeria. During June-September of that year, villages with suspected or confirmed childhood lead poisoning continued to be identified in Zamfara State. OBJECTIVES:We inves...

journal_title：Environmental health perspectives

authors： Lo YC,Dooyema CA,Neri A,Durant J,Jefferies T,Medina-Marino A,de Ravello L,Thoroughman D,Davis L,Dankoli RS,Samson MY,Ibrahim LM,Okechukwu O,Umar-Tsafe NT,Dama AH,Brown MJ

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Cancer may be a stem cell (SC)-based disease involving formation of cancer SCs (CSCs) potentially arising from transformation of normal SCs. Cadmium has been linked to human pancreatic cancer. OBJECTIVE:We studied cadmium exposure of human pancreatic ductal epithelial (HPDE) cells and whether SCs may be tar...

journal_title：Environmental health perspectives

authors： Qu W,Tokar EJ,Kim AJ,Bell MW,Waalkes MP

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVES:The U.S. Environmental Protection Agency is working toward gaining a better understanding of the human health impacts of exposure to complex air pollutant mixtures and the key features that drive the toxicity of these mixtures, which can then be used for future scientific and risk assessments. DATA SOURCES:...

journal_title：Environmental health perspectives

authors： Johns DO,Stanek LW,Walker K,Benromdhane S,Hubbell B,Ross M,Devlin RB,Costa DL,Greenbaum DS

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Maternal factors are implicated in the onset of childhood asthma. Differentiation of naïve CD4+ T lymphocytes into pro-allergic T-helper 2 cells induces interleukin (IL)4 expression and inhibits interferon (IFN)γ expression accompanied by concordant methylation changes in the promoters of these genes. Howeve...

journal_title：Environmental health perspectives

authors： Tang WY,Levin L,Talaska G,Cheung YY,Herbstman J,Tang D,Miller RL,Perera F,Ho SM

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:The association of DDT (dichlorodiphenyltrichloroethane) with breast cancer is controversial, but animal studies directly linking DDT to risk are lacking. Concerns with DDT reside in its environmental persistence, bioaccumulation in breast adipose tissue, and endocrine-disrupting actions. Whereas most attent...

journal_title：Environmental health perspectives

authors： Johnson NA,Ho A,Cline JM,Hughes CL,Foster WG,Davis VL

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Reported associations between gestational tobacco exposure and autism spectrum disorders (ASDs) have been inconsistent. OBJECTIVE:We estimated the association between maternal smoking during pregnancy and ASDs among children 8 years of age. METHODS:This population-based case-cohort study included 633,989 c...

journal_title：Environmental health perspectives

authors： Kalkbrenner AE,Braun JM,Durkin MS,Maenner MJ,Cunniff C,Lee LC,Pettygrove S,Nicholas JS,Daniels JL

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Polybrominated diphenyl ethers (PBDEs) are persistent, bioaccumulative, and endocrine-disrupting chemicals. OBJECTIVES:We used handwipes to estimate exposure to PBDEs in house dust among toddlers and examined sex, age, breast-feeding, race, and parents' education as predictors of serum PBDEs. METHODS:Eight...

journal_title：Environmental health perspectives

authors： Stapleton HM,Eagle S,Sjödin A,Webster TF

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:The incidence of asbestos-induced human cancers is increasing worldwide, and considerable evidence suggests that reactive oxygen species (ROS) are important mediators of these diseases. Our previous studies suggested that mitochondria might be involved in the initiation of oxidative stress in asbestos-expose...

journal_title：Environmental health perspectives

authors： Huang SX,Partridge MA,Ghandhi SA,Davidson MM,Amundson SA,Hei TK

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:The World Health Organization (WHO) released the fourth edition of Guidelines for Drinking-Water Quality in July 2011. In this edition, the 400-µg/L drinking-water guideline for manganese (Mn) was discontinued with the assertion that because "this health-based value is well above concentrations of manganese ...

journal_title：Environmental health perspectives

authors： Frisbie SH,Mitchell EJ,Dustin H,Maynard DM,Sarkar B

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Methylmercury (MeHg) is a known neuro-toxicant. Emerging evidence indicates it may have adverse effects on the neuro-logic and other body systems at common low levels of exposure. Impacts of MeHg exposure could vary by individual susceptibility or be confounded by beneficial nutrients in fish containing MeHg...

journal_title：Environmental health perspectives

authors： Karagas MR,Choi AL,Oken E,Horvat M,Schoeny R,Kamai E,Cowell W,Grandjean P,Korrick S

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Exposure to air pollution has been associated with higher C-reactive protein (CRP) levels, suggesting an inflammatory response. Not much is known about this association in pregnancy. OBJECTIVES:We investigated the associations of air pollution exposure during pregnancy with maternal and fetal CRP levels in ...

journal_title：Environmental health perspectives

authors： van den Hooven EH,de Kluizenaar Y,Pierik FH,Hofman A,van Ratingen SW,Zandveld PY,Lindemans J,Russcher H,Steegers EA,Miedema HM,Jaddoe VW

更新日期：2012-05-01 00:00:00